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Skin Abnormality May Prove Biological Basis for Fibromyalgia By Rick Nauert PhD 3 min readFibromyalgia has long been a conundrum, with pain and widespread functional impairment, but no known biological basis.A new discovery, published in the journal Pain Medicine, may solve the mystery as researchers believe the findings clearly demonstrate that fibromyalgia has a rational biological basis located in the skin.Fibromyalgia is a severely debilitating affliction characterized by widespread deep tissue pain, tenderness in the hands and feet, fatigue, mulberry outlet online sleep disorders, and cognitive decline.However, routine testing has been largely unable to detect a biological basis for fibromyalgia, and standard diagnosis is based upon subjective patient pain ratings, further raising questions about the true nature of the disease.For many years, the disorder was believed to be psychosomatic (”in the head”) and often attributed to patients’ imagination or even faking illness.Currently approved therapeutics that provide at least partial relief to some fibromyalgia patients are thought to act solely within the brain where imaging techniques have detected hyperactivity of unknown origin mulberry outlet store referred to as ”central sensitization.”The breakthrough was made by scientists at Integrated Tissue Dynamics LLC (Intidyn), as part of a fibromyalgia study based at Albany Medical College. Researchers discovered a unique peripheral neurovascular pathology consistently present in the skin of female fibromyalgia patients.They believe this pathology may be a driving source of the reported symptoms.”Instead of being in the brain, the pathology consists of excessive sensory nerve fibers around specialized blood vessel structures located in the palms of the hands,” said Dr. Frank Rice, president of Intidyn and the senior researcher michael kors online outlet on the study.”This discovery provides concrete evidence of a fibromyalgia specific pathology which can now be used for diagnosing the disease, and as a novel starting point for developing more effective therapeutics.”Three years ago, Intidyn scientists published the discovery of an unknown nervous system function among the blood vessels in the skin in the journal PAIN.AsRice explained, ”we analyzed the skin of a particularly interesting patient who lacked all the numerous varieties of sensory nerve endings in the skin that supposedly accounted for our highly sensitive and richly nuanced sense of touch.fz5/05
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